Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Highlights
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SARS-CoV-2 spike protein persists in the skull-meninges-brain axis in COVID-19 patients
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Spike protein is sufficient to induce brain pathological and behavioral changes in mice
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Spike protein enhances brain vulnerability and exacerbates neurological damage in mice
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mRNA vaccines reduce, but do not eliminate, the spike burden
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00438-4